CML

Definition and classification

• What is the CML? A
• What are the myeloproliferative disorder? A, hl317
• What are the clinical phases or types of CML? A, hl
• What is blastic crisis? a

Epidemiology

• How many patients with CML is Ph chromosome positive? Hl
• What is the age incidence of CML? hl

Etiology and Pathophysiology

• Which chromosome is responsible for CML? Hl
• What is Philadelphia (Ph) chromosome? hl
• What are the causes of massive splenomegaly? a

Clinical manifestations

• How does the patient usually present? A, h
• How can you suspect blastic crisis clinically in CML? a

Examinations

• Q

Investigations

• What investigations do you suggest in CML? A, hl
• What is the blood picture of CML? Hl
• What is the bone marrow finding in CML? hl
• Mention one single investigation which will help in diagnosis or exclude other diagnosis. A

Diagnosis

• What are the points in favour of your diagnosis? Hl
• Why is this not myelofibrosis? Hl
• How can you differentiate CML from myelofibrosis? hl

Treatment

• How to treat CML? A, hl
• What is the first line therapy for CML in chronic phase? H
  • How does Imatinib act? Hl
• How can you treat an accelerated phase and blast crisis? Hl
• What are the second generation tyrosin kinase inhibitore? hl
• What are the therapies that may cure CML? A
• What is the prognosis of CML? a

Complications

• What are the causes of death in CML? A, hl