Idiopathic thrombocytopenic purpura

by | May 20, 2017 | Hematology |

Hematology

Definition and classification

  • What is idiopathic thrombocytopenic purpura? A, hl
  • What are the types of ITP? Hl
  • What is purpura? A, hl
  • What are the types of purpura? a

Epidemiology

  • Is it common in male or female? Hl

Etiology and Pathophysiology

  • What is the mechanism of ITP? Hl
  • What are the causes of thrombocytopenia? A
  • What are the causes of purpura? A, h
  • What are the common causes of purpura according to the age? A
  • What are the causes of platelet functional abnormality? a

Clinical manifestations

  • What are the presentations of ITP? A, hl

Examinations

  • In a child, there is purpura in the leg. What else do you want to see? A
  • What should you examine in a patient with purpura? a

Investigations

  • If a patient presents with rash and your suspicion is ITP, which single investigation would you advice? H90
    • What is your expectation in ITP? H91 / What is your expectation in FBC? hl
  • What investigation will you do to confirm your diagnosis? H92
    • What is your expectation? Hl
    • If megakaryocytes are decreased, what will you think? Hl
  • What investigations do you suggest in ITP? A, hl
  • What investigations should be done in purpura? A
  • What is Hess’s test? a

Diagnosis

  • What is the more likely diagnosis? Why? A, hl
  • Why not acute leukemia? A, hl
  • Why not aplastic anemia? A, hl
  • What are the diseases to be excluded, if ITP is suspected? A
  • An 8-year-old girl has purpuric spots on different parts of the body and no other abnormal findings. Her platelet count is 70,000/cmm. What is your diagnosis? H82
  • What are the differences between ITP in children and adults (or acute and chronic ITP)? A
  • What history would you take? Hl
  • How can you differentiate acute ITP from chronic ITP? Hl
  • What are the differential diagnoses of purpura? A
  • How to differentiate in bleeding or purpura whether due to bleeding abnormality or coagulation abnormality? a

Treatment

  • How to treat ITP? A, hl
  • What is the treatment of ITP? hl
  • What are the indications of platelet transfusion in ITP? Hl
  • What are the indications of splenectomy in ITP? Hl
  • How will you treat this patient if she develops menorrhagia without any purpura in ITP? hl
  • What are the indications of OCP in unmarried girl/ medical indications of OCP? Hl

Complications

  • What is the fate of this patient? hl

 

 

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