Primary biliary cirrhosis

Definition

• What is primary biliary cirrhosis? A
• What is secondary biliary cirrhosis? A
• What are the diseases associated with PBC? A, hs
• What is anti-mitochondrial antibody (AMA)? A, hs
  • What are the types? Hs
  • Which is specific for PBC? hs

Epidemiology

• Q

Etiology and Pathophysiology

• What are the causes? A
• Why itching in PBC? A
• What are the causes of granuloma in liver? A
• What are the causes of anemia in PBC? Hs
• Why bleeding tendency (patichae and ecchymosis) occurs in PBC? hs

Clinical manifestations

• How the patient with PBC usually presents? a

Examinations

• Q

Investigations

• What investigations are done in PBC? A, hs

Diagnosis

• Why it is PBC? A, hs
• Why is portal hypertension? hs
• What are your differential diagnoses? A
• Why not this is a case of cirrhosis of liver? A
• Why not hemochromatosis? A
• Why do you consider lymphoma as differential diagnosis? hl

Treatment

• How to treat this patient? A, hs
  • How cholestyramine works? a
• What is the prognosis of PBC? a
  • What is the best indicator for prognosis in PBC? A
• What are the indications of liver transplantation in PBC? a

Complications

• What is the risk of hepatobiliary malignancy in PBC? a