• What is SLE? A
  • From where is the name SLE derived? A
  • What are the types of SLE? A
  • What is ‘disseminated lupus erythematosus’ (DLE)? A
  • What is SCLE (subacute cutaneous lupus erythematosus)? a
  • What is Raynaud’s phenomenon? hl
  • What is anti-phospholipid syndrome? a


  • Q

Etiology and Pathophysiology

  • What are the drugs causing SLE? A
  • What is the relation of pregnancy with SLE? A
  • What is the cause of avascular necrosis of head of femur in SLE? A
  • What is the cause of backache in SLE? a
  • What are the causes of abdominal pain in SLE? a

Clinical manifestations

  • What are the manifestations of SLE? a
  • What are the types of arthritis in systemic lupus erythematosus? A, hl
  • What are the types of rash in systemic lupus erythematosus?, hl
  • Describe a typical systemic lupus erythematosus rash. hl
    • What are the differential diagnoses of butterfly rash? a
  • What are the features of renal involvement in SLE? A
  • What are the atypical features of SLE? a


  • Q


  • What investigations should be done in SLE? A, hl
  • From where biopsy is taken? Hl
  • Which test is done from skin biopsy? Hl
  • How will you send biopsy material to laboratory? hl
  • What are the antibodies found in SLE? a
  • What is anti-ds-DNA? hl
  • What are the causes of positive ANA? A
  • How to diagnose renal involvement in SLE? a


  • Why do you consider this diagnosis? hl
  • What are your differential diagnoses? A
    • Why is this not dermatomyositis? hl
    • Why not rheumatoid arthritis? A, hl
    • Why is this not viral artheritis? hl
  • What are the diagnostic criteria for systemic lupus erythematosus? A, hl
    • How is the diagnosis of systemic lupus erythematosus made? hl
  • What history would you take if you suspect systemic lupus erythematosus? hl
  • A 27-year-old lady presents with symmetrical arthritis of hand joints without any deformity for 6 months. She gives history of two spontaneous abortions. She has malar rash and oral ulcer. What is your diagnosis?


  • Please tell the goals of treatment of systemic lupus erythematosus. Hl
  • How will you treat this patient? hl
  • What are the treatment for systemic lupus erythematosus? A, hl
  • What is the prognosis of systemic lupus erythematosus? hl


  • What are the causes of death in systemic lupus erythematosus? hl
  • What is the mechanism of hemorrhagic cystitis? How to prevent this? a


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