SLE

Definition

• What is SLE? A
• From where is the name SLE derived? A
• What are the types of SLE? A
• What is ‘disseminated lupus erythematosus’ (DLE)? A
• What is SCLE (subacute cutaneous lupus erythematosus)? a
• What is Raynaud’s phenomenon? hl
• What is anti-phospholipid syndrome? a

Epidemiology

• Q

Etiology and Pathophysiology

• What are the drugs causing SLE? A
• What is the relation of pregnancy with SLE? A
• What is the cause of avascular necrosis of head of femur in SLE? A
• What is the cause of backache in SLE? a
• What are the causes of abdominal pain in SLE? a

Clinical manifestations

• What are the manifestations of SLE? a
• What are the types of arthritis in systemic lupus erythematosus? A, hl
• What are the types of rash in systemic lupus erythematosus?, hl
• Describe a typical systemic lupus erythematosus rash. hl
  • What are the differential diagnoses of butterfly rash? a
• What are the features of renal involvement in SLE? A
• What are the atypical features of SLE? a

Examinations

• Q

Investigations

• What investigations should be done in SLE? A, hl
• From where biopsy is taken? Hl
• Which test is done from skin biopsy? Hl
• How will you send biopsy material to laboratory? hl
• What are the antibodies found in SLE? a
• What is anti-ds-DNA? hl
• What are the causes of positive ANA? A
• How to diagnose renal involvement in SLE? a

Diagnosis

• Why do you consider this diagnosis? hl
• What are your differential diagnoses? A
  • Why is this not dermatomyositis? hl
  • Why not rheumatoid arthritis? A, hl
  • Why is this not viral artheritis? hl
• What are the diagnostic criteria for systemic lupus erythematosus? A, hl
  • How is the diagnosis of systemic lupus erythematosus made? hl
• What history would you take if you suspect systemic lupus erythematosus? hl
• A 27-year-old lady presents with symmetrical arthritis of hand joints without any deformity for 6 months. She gives history of two spontaneous abortions. She has malar rash and oral ulcer. What is your diagnosis?

Treatment

• Please tell the goals of treatment of systemic lupus erythematosus. Hl
• How will you treat this patient? hl
• What are the treatment for systemic lupus erythematosus? A, hl
• What is the prognosis of systemic lupus erythematosus? hl

Complications

• What are the causes of death in systemic lupus erythematosus? hl
• What is the mechanism of hemorrhagic cystitis? How to prevent this? a