Cushing’s syndrome

Definition

• Q. What is Cushing’s syndrome?
• Q. What is Cushing’s disease?
• Q. What is pseudo-Cushing’s syndrome?

Epidemiology

• Q

Etiology and Pathophysiology

• Q. What are the causes of Cushing’s syndrome?
  • Q. What are the causes of moon face or puffy face?
  • Q. What are the causes of periorbital edema?
• Q. What is the commonest cause of Cushing’s syndrome?
  • Q. What are the indications of long-term steroid therapy?
  • Q. Tell one absolute indication of steroid therapy.
• Q. What is the difference between Cushing’s disease and Cushing’s syndrome?
• Q. What are the causes of  pseudo-Cushing’s syndrome?

Clinical manifestations

• Q. What are the common features of Cushing’s syndrome?
• Q. What is the cause of back pain in Cushing’s syndrome?
• Q. What is the cause of proximal myopathy?
• Q. What are the striae in Cushing’s syndrome?
  • Q. What is striae? What are the causes?

Examinations

• Q. How would you differentiate clinically different causes of Cushing’s syndrome?
• Q. How would you differentiate clinically pseudo-Cushing’s syndrome from Cushing’s syndrome?
• Q. How can you differentiate striae of Cushing’s syndrome from striae of other causes?

Investigations

• Q. How to investigate this patient?
• Q. What are the biochemical markers of different causes of Cushing’s syndrome?
• Q. Why dexamethasone is used in the suppression test? Why not other steroids like prednisolone?
• Q. Which test would differentiate pseudo-Cushing’s syndrome from Cushing’s syndrome?

Diagnosis

• Q. What are the differential diagnosis?

Treatment

• Q. How will you treat this case?

Complications

• Q. What are the causes of death in Cushing’s syndrome?
• Q. What is Nelson’s syndrome?