Definition

  • Q. What do you mean by thyrotoxicosis?
    • Q. What is factitious thyrotoxicosis?
    • Q. What is thyrotoxic periodic paralysis (TPP)?
  • Q. What do you mean by hyperthyroidism?
  • Q. What are primary and secondary hyperthyroidism?
  • Q. What is Graves’ disease?
    • Q. What is euthyroid Graves’ disease?
    • Q. What is hypothyroid Graves’ disease?

Epidemiology

  • Q

Etiology and Pathophysiology

  • Hyperthyroidism
    • Q. What are the common causes of hyperthyroidism?
    • Q. What is the most common cause of hyperthyroidism?
    • Q. What are the common causes of transient hyperthyroidism?
    • Q. What is the pathogenesis of weight loss in hyperthyroid?
    • Q. What are the causes of tachycardia in hyperthyroidism?
    • Q. What are the causes of primary hyperthyroidism?
  • Thyrotoxicosis 
    • Q. What are the causes of thyrotoxicosis?
    • Q. What are the causes of thyrotoxicosis without hyperthyroidism?
    • Q. What are the common causes of thyrotoxicosis with less of normal iodine uptake?
  • Geaves’ disease
    • Q. What is the cause of Graves’ disease?
    • Q. What is the natural history of Graves’ disease?
    • Q. What is the significance of thyroid bruit?

Clinical manifestations

  • Hyperthyroidism
    • Q. What are the common presentations of hyperthyroidism?
    • Q. Please tell the pathogenesis of weight loss in hyperthyroid.
    • Q. What are the causes of significant weight loss despite good appetite?
    • Q. What are the causes of tachycardia in hyperthyroidism?
  • Graves’ disease
    • Q. What are the clinical triad of Graves’ disease?
    • Q. What are the differences between Graves’ disease and toxic multinodular goiter?
  • Thyrotoxicosis 
    • Q. What are the signs you will find in thyrotoxicosis in head/neck/eye?

Examinations

  • Q. What are the common findings on examination?

Investigations

  • Q. What are the investigations done in hyperthyroidism?
  • Q. What investigations do you suggest in thyrotoxicosis?
  • Q. If single investigation is asked for hyperthyroidism, which one?
  • Q. What are the findings of radio iodine uptake test in thyrotoxicosis?
    • Q. What are the causes of thyrotoxicosis with low radioiodine uptake?

Diagnosis

  • Q. What questions will you ask if you suspect hyperthyroidism?
  • Q. What is your differential diagnosis?

Treatment

  • Q. What are the modalities of treatment of hyperthyroidism?
  • Q. How to treat thyrotoxicosis?
  • Q. Name antithyroid drugs.
  • Q. What are the contraindications of radioactive iodine therapy?
  • Q. What is the role of β-blocker in the treatment of thyrotoxicosis?
  • Q. How to treat thyrotoxicosis with atrial fibrillation?
  • Q. How can you follow up the patient?
  • Q. How will you treat thyrotoxicosis in pregnancy?
  • Q. Why carbimazole is not used in pregnancy?
  • Q. How to treat Graves’ disease?

Complications

  • Q. Tell the complications of thyrotoxicosis with their management?
    • Q. What is the mechanism of thyroid ophthalmopathy? What are the changes and how to treat?
    • Q. What is malignant exophthalmos?
    • Q. What is pretibial myxedema (dermopathy)?
    • Q. Is there any evidence of cancer in Graves’ disease?
  • Q. What is thyrotoxic crisis? How to treat?
  • Q. What are the side effects of antithyroid drugs?
    • Q. What is agranulocytosis?
    • Q. What advice would you give to the patient on antithyroid drugs?
  • Q. What are the complications of radioactive iodine?
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