Motor neuron disease

Definition and classification

• What is MND? A, hl
• What are the types of MND? A
• What is fasciculation? A

Epidemiology

• What is the mean age of onset of MND? hl

Etiology and Pathophysiology

• What are the causes of MND? A
• What is the pathology of MND? A, hl
• What are the patterns of involvement in MND? hl
• What are the causes of fasciculation? a
  • What is the mechanism? A, hl
  • What is the difference between fasciculation and fibrillation of muscle? A
• What is the clinical course of MND? hl

Clinical manifestations

• Which features are strongly against the diagnosis of MND? hl
• What are the causes of wasting of the small muscles of the hand? A
• What are the neurological non-metastatic syndromes of malignancy? a

Examinations

• What are the signs of cerebellar lesion? H131

Investigations

• What investigations should be done in this case? A, hl
• What changes occur in CSF in MND? hl

Diagnosis

• Why it is MND? A, hl
• Why amytrophic lateral sclerosis? A, hl
• Mention one common differential diagnosis to be excluded in such case. A
• What are the differential diagnoses? A
• Why is this not cervical spondylosis? hl
• Could it be syringomyelia? A, hl
• Why is this not myopathy? Hl
• Why is this not peripheral neuropathy? hl
• What are the differences between bulbar and pseudobulbar palsy? a

Treatment

• How to treat MND? A, hl
• Is there any drug which improves survival? hl
• What is the prognosis of MND? A, hl
  • Which type of MND have better prognosis? Hl
  • Which factors are associated with proper prognosis? hl

Complications

• What are the causes of death in MND? Hl